Introductions
Training Sessions
- FACTS Core Introduction
- FACTS Core Dose Response Models
- FACTS Core Predictive Probabilities
- FACTS Core Arm Dropping and RAR
- FACTS Core Multiple Endpoint
- FACTS Core and Enrichment Designs Longitudinal Modeling
- FACTS Core Time-to-Event
- FACTS Core Time-to-Event Predictors
- FACTS Enrichment Designs Introduction
- FACTS Enrichment Designs Hierarchical Modeling
- FACTS Enrichment Designs Borrowing information on control
- FACTS Core and Enrichment Designs Hierarchical Prior for Control
- FACTS Dose Escalation Introduction
- FACTS Dose Escalation N-CRM Setting the Prior
- FACTS Dose Escalation N-CRM Open enrollment, pseudo subjects, expansion cohort, fine spaced doses
- FACTS Dose Escalation N-CRM Ordinal toxicity, 2 samples, efficacy
- FACTS Dose Escalation 2D-CRM
- FACTS Staged Design Introduction
- FACTS Staged Design First Example
- FACTS Staged Design Advanced Topics
- FACTS Dose Escalation - Hands On Training
- FACTS Staged Design - Hands on Training
Introduction to Adaptive Design Using FACTS Webinar Series
Introductory Topics
- The Uses of Trial Simulation in Consulting
- FACTS Core Design Exploration - part 1
- FACTS Core Design Exploration - part 2
- Stopping for Futility
- N-CRM Case Study
- Introduction to Staged Designs
Discussion of FDA Guidance
Response Adaptive Randomization
Case Studies
- The Evolution of a trial from FACTS Core to Staged Design and back
- Using a biomarker endpoint to trigger phase 3
- Designing an Adaptive Multiple Dose Trial with FACTS
- Papers on Bayesian Group Sequential Designs
- The ENRICH trial an Enrichment Design case study
- The ENRICH Trial re-visited
- A seamless phase 2/3 trial in type-2 diabetes
- A two arm study with adherence model driven effect size and irregular interims
- A Phase 1 dose escalation study using open enrolment
- A successful dose finding study in Alzheimer’s
- A two arm non-inferiority MACE safety study
Advance Topics
- Calibrating hierarchical model priors
- Post Processing FACTS output with R
- Using FACTS to analyze Ordinal Data
- FACTS predictive Power and Predicting the Trial Outcomes
- Dose escalation designs with open enrollment
- FACTS Core TTE Predictors
- Early decision making PFS and OS - part 1
- Early decision making PFS and OS - part 2